Company Introduction 회사소개 Vision 비전 Business Area 사업분야 Test Item 시험항목 P&K Skin Research Center Founded in November 2010, P&K Skin Research Center was

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Skin Research Center

Company Introduction 회사소개 Vision 비전 Business Area 사업분야 Test Item 시험항목 P&K Skin Research Center Founded in November 2010, P&K Skin Research Center was established for providing scientific and systematic technical support & information according to various customer s demands about clinical study for developing new ingredients as well as functional cosmetics and quasi-drug. P&K Skin Research Center started through a strategic alliance with the Daebong LS, Ltd., which is the only company manufacturing and selling pharmacuetical & cosmetic & healthy functional food ingreidents, and Chung-Ang University Research Center for Medical Sciences which has first owned a general hospital in Korea. P&K Skin Research Center is equipped with facilities that meet not only the Korean MFDS(Ministry of Food and Drug Safety) and EU guidelines but also the USA Standard. Through analyzing all of functional stroma and protocol from physical through to chemical inspection techniques for pharmaceutical ingredients, and through over 30 years history of Daebong LS, we do the clinical study for the efficacy of general cosmetics and functional ingredients & cosmetics in accordance with Korean MFDS, EU and US functional guideline. Through these scientific evaluations, we are trying to provide scientific technical support and information for customer satisfaction about products directly applied to the skin. We do our utmost to ensure scientific validity, objectivity and also transparency for the evaluation of efficacy & functionality with the Daebong LS Ltd., which has abundant experiences at manufacturing and analysis especially for pharmaceutical & cosmetic ingredients, and our experts including a dermatologist of a university hospital who has various clinical study experiences. 2010년에설립된피엔케이피부임상연구센타는화장품신원료개발, 기능성화장품및의약외품의인체적용시험에대한다양한요구가증가됨에따라과학화된기술지원과정보를제공하고자원료의약품, 화장품원료, 건강기능식품원료등을동시에제조, 판매하는국내유일의회사인대봉엘에스 ( 주 ) 와국내처음으로종합병원을갖춘중앙대학교의학연구소가전략적제휴를통하여설립되었습니다. 피엔케이피부임상연구센타는식약처기준규격과유럽, 미국등의기준에적합한시설설비를갖추고있으며 30년이상역사를가진대봉엘에스 ( 주 ) 의원료의약품에대한이화학적검사기술력을바탕으로모든기능성기질과프로토콜의기작을분석하고이를바탕으로일반화장품의효능검증, 기능성원료및기능성화장품의효능, 의약외품의효능을식약처의기준규격과유럽, 미국등의기준규격에적합한인체적용시험을진행하고있습니다. 인체의피부에직접적용되는제품들에대한과학화된평가를통하여고객만족을위한기술지원및정보를제공하도록노력하고있습니다. 원료의약품과화장품원료를제조하고분석하는분야에경험이풍부한대봉엘에스 ( 주 ) 와의약품및화장품 임상경험이풍부한대학병원의피부과전문의, 전문화된분석평가요원에의한인체적용시험으로효능및기능성 평가에대한과학적타당성, 객관성, 투명성확보를위하여최선을다하고있습니다. 2 P&K Skin Research Center

The philosophy of P&K Skin Research Center toward our customers. P&K Skin Research Center 의고객을향한마음. Validity 타당성 We select our volunteers carefully so as to guarantee the authenticity of data. 엄선된시험대상자관리로신뢰성있는데이터를확보합니다. Objectivity 객관성 We provide clinical study reports both in English and Korean. Our customers can fully check the progress of their clinical studies. 국문과영문보고서를제공하여드립니다. 의뢰하신인체적용시험에대한진행사항을자세히확인하실수있습니다. Transparency 투명성 We provide a raw data as well as its related technical information. 임상로우데이타및관련기술정보를제공해드립니다. Accuracy 정확성 We perform the clinical studies in human races and skin types in accordance with the user s skin and the purposes of application. We promise to keep the schedule of the clinical study in an efficient and punctual manner. 사용자의피부와목적에부합하는인종별, 타입별인체적용시험을진행합니다. 약속한인체적용시험일정을철저히지킵니다. Rationality 합리성 We offer a very reasonable price for our services. Our staff can help customers to predict the outcome of their requested clinical study. 합리적인가격으로인체적용시험을진행합니다. 전문가상담을통한인체적용시험결과를예측할수있습니다. P&K Skin Research Center 3

Company Introduction 회사소개 Vision 비전 Business Area 사업분야 Test Item 시험항목 Why Should We Choose P&K Skin Research Center? 피엔케이피부임상연구센타를 왜 선택해야 하는가? First! First! First! Our P&K Skin Research Center is created by dermatologists who have rich clinical experience in cosmetic & pharmacuetical products, as well as the first medical doctor who specializes in the fields of cosmetic & pharmacuetical raw material manufacturing and analysis techniques done in Korea. P&K Skin Research Center is the first center in Korea, which is entered a strategic alliance with a university hospital medical research center. We do clinical study and basic research work for cosmetics as well as in vitro test and study of skin tissue cells through the university hospital. Through a network with our parent company, Daebong LS Ltd., that has over 35 years of manufacturing and analysis experience in pharmaceutical and cosmetic raw materials, we provide clinical study and analysis services to our customers. 첫째! 국내 최초로 의약품 원료와 화장품 원료, 제조 및 분석 관련하여 경험이 풍부한 전문가와 의약품, 화장품 임상경험이 풍부한 피부과 전문의가 함께 만든 피부임상연구센타입니다. 첫째! 국내 최초로 대학병원을 갖춘 의과대학 의학연구소와 전략적 제휴를 맺은 피부 임상연구센타로 화장품의 임상 및 연구 뿐만 아니라 전임상 또는 피부조직세포 연구도 대학병원을 통해 도와드릴 수 있습니다. 첫째! 원료 의약품과 화장품 원료 분야에서 35년 이상 제조 및 분석에 노하우를 가지고 있으므로, 인체적용시험 뿐만 아니라 분석 분야에서도 도움을 드릴 수 있는 국내 최초의 피부임상연구센타입니다. 4 P&K Skin Research Center

Comprehensive Evaluation and Research of Dermatological Products. 피부임상의 종합적인 평가와 연구 The company thinking the future of skin science. 피부과학의 미래를 생각하는 기업 Scientific and systematic researches with a precision instrument. 정밀기기를 이용한 과학적이고 체계적인 연구 Ensure scientific validity, accuracy, rationality, objectivity, and transparency for efficacy & functional evaluation 효능 및 기능성 평가에 대한 과학적 타당성, 정확성, 합리성, 객관성, 투명성 확보 Scientific technical support and providing information for the customer satisfaction 고객만족을 위한 과학화된 기술지원 및 정보제공 A responsible clinical efficacy evaluation by the best specialists 최고의 전문의에 의한 책임 있는 인체적용시험 효능 평가 P&K Skin Research Center 5

Company Introduction 회사소개 Vision 비전 Business Area 사업분야 Test Item 시험항목 Cosmetic Raw Materials 화장품원료 General Cosmetics 일반화장품 Functional Cosmetics 기능성화장품 Functional Foods 건강기능식품 Cosmetotextiles 공산품 ( 의류 ) In Vitro In Vitro 평가 Chung-Ang University Research Center for Medical Sciences 중앙대학교의학연구소 Dermatologist & Specialized Clinical Researchers 피부과전문의전문화된분석평가요원 6 P&K Skin Research Center

Safety Evaluation 안전성평가 Safety Assessment by skin application Skin Efficacy Evaluation 피부효능평가 Skin Care Product : Anti-Wrinkle, Skin Whitening, Sunscreen etc. Make-up Product : Make-up persistency, Make-up Water proof etc. Lip Care Product : Moisture, Roughness, Desquamation, Volume etc. Hair & Scalp Efficacy Evaluation 헤어 & 두피효능평가 Hair Dye, Depilatory, Hair Loss, Scalp Moisture, Anti-Dandruff etc. Functional Foods Evaluation 건강기능식품평가 Constipation, Slimming, Hangover etc. Cosmetotextiles 공산품 ( 의류 ) Skin Moisture, Elasticity, Slimming etc. In Vitro Evaluation In Vitro 평가 Cytotoxicity, Antioxidant, Anti-wrinkle, Whitening etc. Providing Clinical Study Result 인체적용시험결과제공 Providing scientific & specialized information for a clinical study Providing Technical Information 기술정보제공 Providing know-how & technical information for a clinical study * MFDS: Ministry of Food and Drug Safety P&K Skin Research Center 7

Company Introduction 회사소개 Vision 비전 Business Area 사업분야 Test Item 시험항목 Safety Tests 안전성평가 Human Skin Primary Irritation Test 인체피부 1 차자극시험 Human Skin Repeat Insult Patch Test 인체피부누적자극및감작성시험 In-Use Test 인체피부사용성시험 Human Skin Stinging Potential Test 인체피부민감성시험 Skin Efficacy Tests 기능성화장품시험 Wrinkle Test 주름개선기능평가 Depilatory Test 제모력시험 Whitening Test 미백기능평가 Sunscreen Test(SPF,PFA,Water resist) 자외선차단기능평가 Acne Test 여드름시험 Hair Dye Test 염모력시험 Stretch Mark Test 튼살개선시험 Hair Loss Test 탈모방지시험 8 P&K Skin Research Center

Skin Efficacy Tests 피부효능평가시험 Skin Desquamation Improvement Test 피부각질평가시험 Dead skin cell images before & after use Skin Black-Heads Improvement Test 피부블랙헤드평가시험 Skin black-head images before & after use Skin Pore(Area, Number) Improvement Test 피부모공 ( 면적, 수 ) 평가시험 Skin pores images before & after use Skin Sebum Test 피부유분 / 피지평가시험 Skin sebum images before & after use Human Skin Elasticity Improvement Test 피부탄력개선시험 Skin Restitution(Restoring) Improvement Test 피부복원력 ( 회복력 ) 평가시험 Dermal Elasticity Improvement Test 피부진피탄력평가시험 Vertical Elongated Pore Improvement Test 세로모공평가시험 Skin Moisture Test 피부보습시험 Dermal Moisture Test 피부진피보습시험 Skin Anti-Aging Improvement Test 피부항노화 ( 안티에이징, 피부노화 ) 평가시험 Trans Epidermal Water Loss Test 경표피수분손실량 (TEWL) 평가시험 P&K Skin Research Center 9

Company Introduction 회사소개 Vision 비전 Business Area 사업분야 Test Item 시험항목 Skin Efficacy Tests 피부효능평가시험 Damaged Skin Improvement Test 피부손상개선평가시험 Damaged skin images before & after use Skin Density Improvement Test 피부진피치밀도평가시험 Skin density images before & after use Face Lifting Improvement Test 안면리프팅평가시험 Face Lifting images before & after use Skin Texture Improvement Test 피부결평가시험 Skin Texture images before & after use Skin Uniformity(evenness) Improvement Test 피부균일도평가시험 Skin Translucenty Improvement Test 피부투명도평가시험 Skin Tone/ Lightness Improvement Test 피부톤 / 밝기평가시험 Skin Melanin & Brown Spot Improvement Test 멜라닌감소및갈색스팟개선시험 Skin Glossiness Improvement Test 피부광택 ( 윤기 ) 평가시험 Skin Thickness Improvement Test 피부두께평가시험 Body Lifting Improvent Test 바디리프팅평가시험 Skin Volume Improvent Test 피부볼륨증가시험 10 P&K Skin Research Center

Skin Efficacy Tests 피부효능평가시험 Temporal Skin Temperature Decrease (cooling effect) Test 일시적피부온도감소 ( 쿨링효과 ) 평가시험 Skin temperature images before & after use Skin Cleansing effect Test 피부세정력평가시험 Skin cleansing images before & after use Skin Adherence effect Test on color cosmetics 색조제품피부밀착력평가시험 Original & extraction images in make-up persistency Make-up Persistency(color persistency) Test 메이크업지속력 ( 색상지속력 ) 평가시험 Make-up persistency images before & after use Skin Heat protection Test 피부열차단평가시험 Lip Roughness Improvement Test 입술거칠기평가시험 Lip Moisture Improvement Test 입술수분평가시험 Lip Glossiness Improvement Test 입술윤기평가시험 Skin Wrinkle/Pore cover effect Test 피부주름 / 모공커버평가시험 Waterproof effect Test on color cosmetics 색조제품워터프루프평가시험 Mascara Curling effect Test 마스카라컬링력평가시험 Eye Iashes Length Test 속눈썹길이평가시험 P&K Skin Research Center 11

Company Introduction 회사소개 Vision 비전 Business Area 사업분야 Test Item 시험항목 Skin Efficacy Tests 피부효능평가시험 ( 식약처실증가이드라인시험 ) Skin scanner image on thigh Cellulite Temporal Cellulite Reduction Test 일시적셀롤라이트감소시험 Skin swelling 3D images before & after use Skin Swelling Improvement Test 피부붓기완화평가시험 Dark-Circle images before & after use Human Skin Dark-Circle Relief Test 다크서클완화시험 Skin blood circulation(micro) images before & after use Skin Blood Circulation(micro) Improvement Test 피부혈행평가시험 Special Evaluations 기타시험 In Vitro Evaluations In Vitro 시험 Dust & Pollution Test 더스트 & 폴루션시험 Cytotoxicity Test 세포독성시험 Anti-oxidant Test 항산화시험 Anti-wrinkle Test 주름시험 Whitening Test 미백시험 Anti-inflammatory Test 항염시험 Atopy Test 아토피시험 Anti-Bacterial Test 아토피시험 EEG Test 뇌파시험 12 P&K Skin Research Center

Hair & Scalp Efficacy Tests 헤어 & 두피효능평가시험 Hair Volume Test 헤어볼륨력평가시험 Hair volume images before & after use Hair Glossiness Test 모발광택 ( 윤기 ) 평가시험 Original & extraction images in hair glossiness Hair Curl Retention Effect Test 모발컬유지력평가시험 Hair curl images before & after use Anti-Dandruff Test 비듬방지평가시험 Anti-dandruff images before & after use Scalp Moisture Test 두피보습평가시험 Scalp Sebum Test 두피유분평가시험 Scalp Desquamation Test 두피각질평가시험 Scalp Redness Test 두피붉은기평가시험 Scalp Cleansing Effect Test 두피세정력평가시험 Hair Root Volume Test 신생모 ( 뿌리 ) 볼륨평가시험 P&K Skin Research Center 13

Company Introduction 회사소개 Vision 비전 Business Area 사업분야 Test Item 시험항목 Hair & Scalp Efficacy Tests 헤어 & 두피효능평가시험 Damaged Hair Improvement Test 모발손상개선평가시험 Hair SEM images before & after use Split Hair End Improvement Test 모발끝갈라짐개선평가시험 Hair split end images before & after use Generic Tensile Tester - MTT175 Hair Permanent-wave Retention(Curl-up) effect Test 파머넌트웨이브유지력 ( 컬업 ) 평가시험 Hair Straightening Retention effect Test 스트레이트유지력평가시험 Hair Moisture Test 모발수분량평가시험 Hair Protection Test 모발보호평가시험 Hair Friction Test 모발마찰력평가시험 Hair Elasticity Test 모발탄력평가시험 Hair Combing Test 모발컴빗평가시험 Hair Color Persistency Test 모발색상유지력평가시험 14 P&K Skin Research Center

ISO Certificate ISO 인증서 Articles 논문 01. A Study of Potential Application of Rubus coreanus Miquel Extract for Seborrheic Dermatitis Treatment, Korean Journal of Medical Mycology, 2011. 02. Skin Hydration, Transepidermal Water Loss and Relation with Tinea Pedis in Patients with Primary Hyperhidrosis, Korean Journal of Medical Mycology, 2011. 03. The Effect of the Mixed Herbal Extract Lotion for Korean Patient with Atopic Dermatitis: A Pilot Study, Journal of Asthma, Allergy and Clinical Immunology, 2012. 04. The Evaluation of Skin Safety and Skin Cell Toxicity for Scutellaria baicalensis Georgi Extract according to Extraction Conditions, Korean Journal of Dermatology, 2012. 05. Efficacy of adenosylcobalamin in relieving xerotic pruritus symptoms of atopic dermatitis, Journal of the European Academy of Dermatology and Venereology, 2013. 06. A method of facial pore size evaluation, The Journal of Skin Barrier Research, 2013. 07. The Efficacy of Cleansing Device with a Rotating Brush on the Skin, Journal of the Society of Cosmetic Scientists of Korea, 2013. 08. Sun Protection Factor (SPF) Assessment of the Sunscreen Composed of Natural Substances, Journal of the Society of Cosmetic Scientists of Korea, 2013. 09. The Characteristics of Skin Water Content, Sebum Content, and Transepidermal Water Loss from Trial Subjects, Journal of the Society of Cosmetic Scientists of Korea, 2013. 10. Characteristic of MED measurement Value of Trial Subjects from Ultraviolet Irradiation, Journal of the Society of Cosmetic Scientists of Korea, 2013. 11. The effect of lymph drainage massage using natural cosmetics on moisture, sebum and pores of facial skin, Journal of Korean Beauty Society, 2013. 12. Improvement in skin wrinkles with use of a preparation containing human growth factors and hyaluronic acid serum, Journal of Cosmetic and Laser Therapy, 2014. 13. Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehiclecontrolled trial, Skin Research and Technology, 2014. 14. Extracting skin roughness from dermoscopy images for skin age estimation, Journal of Korea Information Processing Society, 2014. 15. Unwanted hair growth induced by topical epidermal growth factor during wound healing: true or myth?, International Wound Journal, 2014. 16. Efficacy of adenosylcobalamin in relieving xerotic pruritus symptoms of atopic dermatitis, Journal of the European Academy of Dermatology and Venereology, 2014 17. A quantitative evaluation method using processed optical images and analysis of age-dependent changes on nasolabial lines, Skin Research & Technology, 2015 P&K Skin Research Center 15

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