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1 Original Article Korean J Health Promot 2011;11(4): pissn: eissn: 신체활동량의차이가중강도트레드밀달리기에따른유리지방산, 글루코스, 성장호르몬, 인슐린및주관적식욕에미치는영향 박해찬 1, 박성규 1, 이진석 1, 최연주 1, 안수경 1, 윤성진 2 1 고려대학교운동생리학실험실, 2 고려대학교사범대학체육교육과 The Effects of Moderate Treadmill Running on Free Fatty Acids, Glucose, Growth Hormone, Insulin and Appetite Hae-Chan Park 1, Sung-Kyu Park 1, Jin-Seok Lee 1, Yeon-Ju Choi 1, Su-Kyoung Ahn 1, Sung-Jin Yoon 2 1 Exercise Physiology Laboratory, Korea University, Seoul, 2 Department of Physical Education, Korea University College of Education, Seoul, Korea Background: The level of physical adaptation through active lifestyle can result in changes in appetite; and caused by physical activity and exercise, physical adaptation may change carbohydrate and fat metabolism during exercise. This study investigated the differences in carbohydrate and fat metabolism after moderate treadmill running and the difference in appetite response before and after exercise in active, regularly exercising individuals and those inactive. Methods: We analyzed the effects of moderate physical activity (70% of oxygen uptake reserve, 30 minutes on the treadmill) on free fatty acids, glucose, growth hormone, insulin and an appetite visual analogue scale (VAS). Our subjects included 28 healthy males who were divided into two groups, the activity group (n=14) and the inactivity group (n=14) according to the International Physical Activity Questionnaire (IPAQ). The serum samples and VAS were collected at pre, post and 30 min post-exercise. Results: The results of the serum analysis showed no significant effects on free fatty acids, glucose, growth hormone and insulin between the groups, but showed significant changes in free fatty acids and growth hormone between points of measurement. Significant increases in VAS were seen with moderate exercise in both groups, with the inactivity group expressing greater hunger than the activity group. Conclusions: This study found that inactive persons were hungrier than active persons after moderate exercise. This information might be useful to staff and participants of weight loss programs. Korean J Health Promot 2011;11(4): Keywords: Physical activity, Energy metabolism, Hormone, Appetite 서 론 산업혁명이후기계문명의발달로생산성의증가와자동화가보편화되면서사람들에섭식량은증가한반면, 신 Received:August 10, 2011 Accepted:November 16, 2011 Corresponding author:sung-jin Yoon, PhD Department of Physical Education, Korea University College of Education, 145 Anam-ro, Seongbuk-gu, Seoul , Korea Tel: , Fax: jiss@korea.ac.kr 체활동량은감소하였다. 이러한변화는고혈압, 당뇨, 고지혈, 비만등각종생활습관병발생에주요원인이되고있으며, 현재사회적으로나개인적으로큰문제가되고있다. 1) 생활습관병예방및완화를위해선행연구에서는섭식량을조절하고신체활동량을증가시키는것이가장효과적이고효율적인방법이라고보고하고있다. 2) 이처럼건강을위해일상생활에서조절되어야하는섭식과신체활동은상호영향을주고받는것으로보고하고있으며, 무엇보다신체활동및운동의강도, 시간, 빈도등이섭식욕구즉식욕에영향을주는

2 Hae-Chan Park, et al. The Effects of Moderate Treadmill Running on Free Fatty Acids, Glucose, Growth Hormone, Insulin and Appetite 235 것으로보고하고있다. 3-5) 이와관련하여선행연구에서는낮은수준의신체활동이나저강도운동은식욕에영향을주지못하지만높은수준의신체활동이나고강도운동은허기를유발하여식욕을촉진할수있다고보고하였다. 그리고단시간의신체활동과운동보다는장시간의신체활동과운동이식욕촉진효과가크다고보고하였다. 6,7) 한편, 다른선행연구에서운동에의한식욕의변화가운동에의해소비되는에너지에많고적음이영향을주는것으로보고하고있다. 8) 특히, 높은수준의신체활동이나고강도의운동을장시간실시할때많은양의에너지를소비하게되는데, 인체는체내에너지균형을위해소비한에너지에대한보상작용중하나로식욕수준을증가시켜섭식량을증가시킨다고보고하고있다. 8,9) 운동에의한식욕의변화에서운동의강도와시간은식욕의변화에주요하게작용하는요인이라고할수있지만, 보다비중있게영향을미치는요인은운동에의해소비된에너지량즉, 총운동량이라고본연구자는생각한다. 운동에의한식욕의변화는체내대사의변화와높은관련성을갖는데, 선행연구에서는에너지대사기질인유리지방산과글루코스, 에너지대사부산물인젖산, 에너지대사조절호르몬인인슐린과성장호르몬등의변화에영향을받는것으로보고하고있다 ) 예컨대, 일상에서의신체활동이나운동중에너지대사에에너지원으로사용되는기질과식욕간의관계에서유리지방산은증가할수록, 글루코스는감소할수록식욕은증가하는것으로보고하고있다 ) 운동중이러한에너지대사기질의사용비율과양은일정기간의규칙적인운동즉, 트레이닝에의해바뀔수있는데, 트레이닝에의해운동중탄수화물대사의비율은상대적으로낮아지고지방대사의비율은상대적으로높아지는것으로보고하고있다 ) 그리고이러한변화는에너지대사조절을담당하는호르몬인인슐린과성장호르몬등의변화도동반케하는것으로보고하고있다. 16) 운동에의한에너지대사는일반적으로트레이닝에의해변화하는것으로알려져있지만, 본연구자는일상생활에서습관적으로높은신체활동수준을유지하고있다면, 그습관에의해서일정수준의트레이닝효과를얻을수있고에너지대사의변화또한, 나타날것으로생각한다. 운동에의한식욕의변화가특정운동강도나시간보다는총에너지소비량에영향을받고일상생활에서의신체활동이일정수준의트레이닝효과를갖는다면, 본연구자는불규칙적인운동을포함하여활동적으로생활한사람과신체활동이거의없는비활동적인사람간에운동에따른식욕의반응은차이가있을것으로생각한다. 따라서이연구에서는건강을위해일반적으로권장되는중강도트레드밀달리기에따른활동집단과비활동집단간에에너지대사기질인유리지방산, 글루코스의변화와에너지대사조절에관여하는호르몬인인슐린, 성장호르몬의변화를알아보고자한다. 2) 그리고보다명확한식욕의변화를알아보기위해주관적인식욕반응을 VAS (visual analogue scale) 를통해측정하여검토하고자한다. 방법 1. 연구대상 본연구는활동적인남성과비활동적인남성각 14명을대상으로실시하였다. 활동집단 (activity group) 은주 3일이상, 중강도이상으로불규칙적인운동을포함하여운동량이 1500 MET-min/week 를초과하는자로하였으며, 비활동집단 (inactivity group) 은규칙적으로운동을하지않으며, 활동량이 600 MET-min/week 미만인자로하였다. 연구대상자는실험참가전실험의내용과절차에대한설명을듣고, 실험참가동의서를작성하였다. 본연구의대상자에신체적특성은표 1과같다. 2. 측정항목 1) 신체구성검사연구대상자의신체적특성은측정 10시간전까지식사나운동을금한후, 반소매면셔츠와면반바지만착용한 Table 1. Characteristics of study subjects a Groups Activity (n=14) Inactivity (n=14) N Age, y 24.6± ±2.1 Height, cm 176.0± ±4.6 Weight, kg 72.5± ±10.8 Body mass Index, kg/m ± ±3.5 Amount of physical activity, MET-min/wk ± ±92.5 V O 2max, ml/kg/min 47.4± ±5.7 Abbreviation: V O 2max, maximal oxygen uptake. Data are presented as mean±sd.

3 236 Korean J Health Promot Vol. 11, No. 4, 2011 상태로자동신장체중계 (DS-102, Dong-sahn Jenix, Seoul, Korea) 와생체전기저항측정기 (Inbody 2.0, Biospace, Seoul, Korea) 를사용하여신장, 체중, 체질량지수를측정하였다. 2) 운동부하검사본연구의대상자는트레드밀에서 Korea Institute Sports Science (KISS) 프로토콜을사용하여운동부하검사를실시하였다. 19) 운동부하검사의시작은경사도 3% 고정한후 2.5 miles per hour (mph) 의속도로시작하여, 매 2분마다 0.5 mph씩증가시켜탈진까지운동을실시하였다. 이때운동은실험참가자가탈진할때까지지속하였으며, 검사중단기준은연구대상자의상태와호흡교환율 1.15 이상일때, 운동강도가증가함에도불구하고산소섭취량이고원상태를유지할때로하였다. 20) 호흡가스는 Metabolic Cart 자동가스분석기 (Quack b2, Rome, Italy) 를이용하여분석하였고분석한자료를토대로최대산소섭취량 (maximal oxygen uptake, V O 2max) 을산출하였다. 3) 신체활동량측정신체활동량을측정하기위해국제신체활동질문지 (International Physical Activity Questionnaire, IPAQ) 를사용하였다. 본연구에서는 IPAQ 중단축형 (short form) Table 2. Total work MET calculations Walking MET=3.3 walking minutes walking days Moderate MET=4.0 moderate minutes moderate days Vigorous MET=8.0 vigorous minutes vigorous days Total work MET=walking MET+moderate MET+vigorous MET Abbreviation: MET, metabolic equivalent of task. Table 3. Oxygen uptake reserve calculation 70%V O 2R=[(V O 2max-V O 2rest) 70/100]+V O 2rest Abbreviations: V O 2R, oxygen uptake reserve; V O 2max, maximal oxygen uptake; V O 2rest, oxygen uptake rest. 을사용하였으며, IPAQ 단축형질문지는일주일동안에걷기, 중강도, 고강도등의활동에대한빈도 (day/week) 와시간 (minute/day) 을작성하도록구성되어있다 (Table 2). 21) 신체활동량은 MET-minutes/week 로산출되며, 질문결과의정확도를높이기위해 4주동안총 4회에걸쳐질문지를작성하고평균값을산출하여사용하였다. 4) 혈액분석혈액은오전 9에서 10시사이공복에채취하였고, 채취시점은운동전, 운동직후, 운동종료 30분에실시하였다. 본연구의대상자는트레드밀달리기를최대여유산소섭취량 (oxygen uptake reserve, V O 2R) 의 70% 의운동강도로 30 분동안실시하였고운동강도에대한계산식은표 3과같다. 2) 혈액은상완정맥에서 5 ml를채취하여응고를위해실온에서 30분동안보관한후, 3000 rpm으로 10분동안원심분리하고혈구와혈장으로분리한후, -70 에냉동보관하였다. 채취한혈액으로유리지방산, 글루코스, 성장호르몬, 인슐린을분석하였고각변인의분석방법은표 4 와같다. 5) 주관적식욕측정주관적인식욕은 VAS 9점척도를이용하여측정하였으며, 척도의왼쪽끝 1 은 매우포만한 으로, 척도의오른쪽끝 9 는 매우허기진 으로설정하여식욕 ( 허기 ) 이증가할수록높은숫자를표시하도록하였다. 22) 측정시점은혈액채취시점과동일한운동전, 운동직후, 운동종료 30분에실시하였다. 3. 자료처리및분석 본연구에대한통계처리는 SPSS Ver 프로그램을이용하여시행하였다. 주자료의정규성검정은 Shapiro-Wilk 검정법을이용하여시행하였으며, 모든자료가정규성임 Table 4. Methods of blood analysis Items FFA Glucose Insulin GH Method ACS-ACOD Enzymatic method ECLIA CLIA (colorimetry method) Reagent Kit NEFA HR.Ⅱ Glucose Insulin Immulite Product Hexokinase 2000 GH Kit company Wako SIEMENS Roche SIEMENS Country Japan USA Germany USA Equipment Analysor Hitachi ADVIA Modular Analytics Immulite 2000 Product HITACHI 7180 ADVIA 1650 E170 Immulite 2000 Company HITACHI SIEMENS Roche DPC Country Japan USA Germany USA Abbreviations: FFA, free fatty acid; GH, growth hormone; ACS-ACOD, acetyl coa synthetase-acetyl coa oxidase; ECLIA, electrochemiluminescence immunoassay; CLIA, chemiluminescence immunoassay.

4 Hae-Chan Park, et al. The Effects of Moderate Treadmill Running on Free Fatty Acids, Glucose, Growth Hormone, Insulin and Appetite 237 을확인하였다. 이에, two-way analysis of variance를사용하여시점과집단간차이와교호작용을알아보았다. 통계학적유의수준은 0.05 미만으로정하였다. 결과 1. 유리지방산 두집단의시점과집단간의변화를검정하였다 (F=0.304, P=0.740). 성장호르몬의변화에대한시점에따른 F 값은 이고유의확률은 <0.001 로시점간유의한차이가있었다. 하지만, 집단간효과검정에서 F 값은 0.025이고유의확률은 0.875로집단간에유의한차이가없었다. 4. 인슐린 표 5는활동집단과비활동집단간유리지방산의변화에대한결과이다. 시점과집단간에교호작용이없으므로두집단의시점과집단간의변화를검정하였다 (F=2.392, P=0.112). 유리지방산의변화에대한시점에따른 F 값은 이고유의확률은 <0.001로시점간유의한차이가있었다. 하지만, 집단간효과검정에서 F 값은 0.203이고, 유의확률은 0.656으로집단간에유의한차이가없었다. 2. 글루코스 표 6은활동집단과비활동집단간글루코스의변화에대한결과이다. 시점과집단간에교호작용이없으므로두집단의시점과집단간의변화를검정하였다 (F=0.662, P=0.525). 글루코스의변화에대한시점에따른 F 값은 2.520이고유의확률은 0.101로시점간유의한값은 이고유의확률은 0.614로집단간에유의한차이가없었다. 3. 성장호르몬 표 7은활동집단과비활동집단간성장호르몬의변화에대한결과이다. 시점과집단간에교호작용이없으므로 Table 5. Changes in free fatty acid a (μeq/l) Activity ± ± ±149.1 e Inactivity ± ± ±385.3 e e P<0.01, difference in levels between measured times. Table 6. Changes in glucose a (mg/dl) Activity ± ± ±11.9 Inactivity ± ± ±5.5 표 8은활동집단과비활동집단간인슐린의변화에대한결과이다. 시점과집단간에교호작용이없으므로두집단의시점과집단간의변화를검정하였다 (F=0.310, P=0.736). 인슐린의변화에대한시점에따른 F 값은.433 이고유의확률은 0.108로시점간유의한차이가없었다. 또한, 집단간효과검정에서 F 값은 0.421이고유의확률은 0.522로집단간에유의한차이가없었다. 5. 주관적식욕 표 9는활동집단과비활동집단간주관적식욕 (VAS) 에대한결과이다. 시점과집단간에교호작용이없으므로두집단의시점과집단간의변화를검정하였다 (F=1.579, Table 7. Changes in growth hormone a (ng/ml) Activity ± ± ±1.66 e Inactivity ± ± ±2.61 e e P<0.01, difference in levels between measured times. Table 8. Changes in insulin a (μu/ml) Activity ± ± ±6.04 Inactivity ± ± ±1.45 Table 9. Scores of appetite visual analogue scale a (point) Activity e ± ± ±1.70 f Inactivity ± ± ±0.89 f e P<0.01, difference in levels between measured times. f P<0.05, difference in levels between groups.

5 238 Korean J Health Promot Vol. 11, No. 4, 2011 P=0.226). 주관적식욕에대한시점에따른 F 값은 이고유의확률은 <0.001 로시점간유의한차이가있었다. 또한, 집단간효과검정에서 F 값은 5.357이고유의확률은 0.029로집단간에유의한차이가있었다. 고 찰 본연구에서는성인남성을대상으로신체활동에따라활동집단과비활동집단으로분류하여일반적으로권장되는중강도운동에따른에너지대사기질과에너지대사에관여하는호르몬의차이를알아보았다. 또한, 두집단간에중강도운동에따른식욕의차이를알아보았다. 활동집단과비활동집단간에에너지대사기질인유리지방산과글루코스의변화를검토한결과, 유리지방산과글루코스모두집단간에차이가없었고유리지방산에서만시점간에유의한변화가있었다 (Table 5, 6). 수치상의경향에서글루코스는집단간특이한차이가없었던반면에, 유리지방산은운동전과운동직후간에활동집단이비활동집단보다크게증가하는경향을나타냈다 (Table 5). 그리고운동직후와운동종료 30분간에활동집단이비활동집단보다크게감소하는경향을나타냈다 (Table 5). 이러한결과는본연구에서설정한활동집단과비활동집단간의신체활동수준에차이가중강도운동전 후의유리지방산과글루코스에유의한영향을주지못한다는것을의미한다. 하지만, 집단간유리지방산의수치상에결과는평소신체활동수준이높은사람이낮은사람보다중강도운동에따른에너지대사에서유리지방산에이화작용이보다높게일어날가능성을제시하는것이라고생각한다. 그리고운동직후와운동종료 30분에활동집단이비활동집단보다유리지방산이빠르게감소한이유는두집단간회복능력의차이에의해나타난결과라고생각한다. 중강도운동에따른유리지방산과글루코스의시점에따른결과는선행연구의결과와유사하게나타났다. 23,24) 다수의연구에서안정시에너지대사나저강도의신체활동중에너지대사는탄수화물대사보다는지방대사가에너지대사에공헌하는비율이높은것으로보고하고있다. 24) 운동이시작되면탄수화물대사의비율이점차높아지는데, 운동의초반일수록탄수화물대사비율이상대적으로높고운동이후반으로진행될수록지방대사의비율이상대적으로높아진다고보고하고있다. 23) 본연구또한, 두집단모두운동전과비교해서운동직후에지방대사의주요에너지원인혈중유리지방산은약 2-3배증가가나타난반면, 탄수화물에주요에너지원인혈중글루코스는큰차이가없는것으로나타났다 (Table 5, 6). 활동집단과비활동집단간에에너지대사에관여하는호르몬인성장호르몬과인슐린의변화를검토한결과, 성장호르몬과인슐린모두집단간에차이가없었고성장호르몬에서만시점간에유의한변화가있었다 (Table 7). 수치상의경향에서성장호르몬은집단간특이한차이가없었던반면에, 인슐린은시점에따른두집단의변화간에차이가나타났다. 활동집단은운동에의해인슐린이감소하는경향을보이다가운동종료 30분에는다시증가하여안정시와비슷한상태로돌아오는경향을나타낸다 (Table 8). 하지만, 비활동집단은운동전부터운동종료 30분까지계속적으로인슐린이감소하는경향을나타냈다 (Table 8). 이러한결과는본연구에서설정한활동집단과비활동집단간의신체활동수준에차이가중강도운동전 후의성장호르몬과인슐린에유의한영향을주지못한다는것을의미한다. 비록, 수치상의차이지만, 시점에따른두집단의인슐린변화에차이는본연구의유리지방산에서와마찬가지로운동종료후, 안정상태로회복하는능력에차이에의해나타난결과라고생각한다. 규칙적인운동은안정시나운동시에너지대사에변화를가져오는데, 안정시지방대사량을높이고인슐린에대한민감도를증가시켜운동시보다적은양으로근세포의글루코스유입을원활하게하는것으로보고되고있다. 16,25,26) 그리고규칙적인운동에의해안정시인슐린농도가감소할수있다고보고되고있다. 27) 하지만, 본연구에서는일상생활의신체활동량에많고적음을기준으로집단을분류했기때문에활동집단과비활동집단간성장호르몬과인슐린변화에명확한차이가나타나지않았던것으로생각한다. 주관적식욕 (VAS) 의변화를검토한결과, 두집단모두중강도운동에의해식욕 ( 허기 ) 증가가나타났고활동집단보다비활동집단에서더높은식욕증가가나타났다 (Table 9). 본연구에서검토한유리지방산과글루코스와같은에너지대사기질과성장호르몬과인슐린과같은에너지대사에관여하는호르몬은식욕을조절하는호르몬인렙틴, 그렐린등에직 간접적으로영향을주는것으로알려져있다. 13,28,29) 선행연구에서는유리지방산이증가하거나글루코스가감소하면식욕이증가하는것으로보고되고있고 13-15) 성장호르몬이증가하거나인슐린이감소하여도식욕이증가하는것으로보고되고있다 ) 이러한선행연구의결과와유사하게본연구에서도집단간유의한차이는나타나지않았지만, 활동집단보다비활동집단이유리지방산과성장호르몬에수치가상대적으로높고글루코스와인슐린의수치가상대적으로낮은것으로나타났다 (Table 5-8). 본연구에서나타난식욕의변화가평소신체활동수준에절대적으로영향을받아나타난결과

6 Hae-Chan Park, et al. The Effects of Moderate Treadmill Running on Free Fatty Acids, Glucose, Growth Hormone, Insulin and Appetite 239 라고단정하여설명할수는없다. 하지만, 본연구의결과를통해평소활동적인사람보다비활동적인사람이중강도운동후허기진정도가심하며, 식욕수준이높을것이라는가능성을제시한다. 요약 연구배경 : 활동적으로생활을했을때일어나는신체적적응의차이가식욕의변화에영향을줄수있으며, 신체활동과운동에의해일어나는신체적적응은운동중지방대사와탄수화물대사의비율을변화시킬가능성이있다. 이에, 본연구에서는규칙적인운동을포함하여활동적으로생활한사람과신체활동이거의없는비활동적인사람간에중강도트레드밀달리기에따른탄수화물및지방대사에차이를알아보고이들간에운동전 후식욕반응의차이를알아보았다. 방법 : 본연구에서는성인남성, 28명을대상으로활동집단 (n=14) 과비활동집단 (n=14) 간에중강도운동 ( 트레드밀달리기, 최대여유산소섭취량 (V O 2R) 의 70%, 30분 ) 에따른유리지방산, 글루코스, 성장호르몬, 인슐린, 주관적식욕의변화를알아보았다. 중강도운동에따른혈액채취와주관적식욕에대한평가는운동전, 운동직후, 운동종료 30분에실시하였다. 결과 : 혈액분석결과, 유리지방산, 글루코스, 성장호르몬, 인슐린은집단간에유의한차이가없었으며, 유리지방산 (F=41.150, P<0.001) 과성장호르몬 (F=32.455, P<0.001) 은시점간에유의한변화가있었다. 수치상의변화를살펴보면, 유리지방산은운동전과운동직후간에활동집단이비활동집단보다크게증가하는경향을나타냈고운동직후와운동종료 30분간에활동집단이비활동집단보다크게감소하는경향을나타냈다. 인슐린은활동집단에서중강도운동에의해감소하는경향을보이다가운동종료 30분에는다시증가하여안정시와비슷한상태로돌아오는경향을나타낸다. 하지만, 비활동집단은운동전부터운동종료 30분까지계속적으로인슐린이감소하는경향을나타냈다. 주관적식욕에서는두집단모두중강도운동에의해식욕증가가나타났고 (F=26.483, P<0.001) 활동집단보다비활동집단에서더높은식욕증가가나타났다 (F=5.357, P=0.029). 결론 : 본연구의결과로, 평소활동적인사람보다비활동적인사람이중강도운동후허기진정도가심하며, 식욕수준이높을것이라는가능성을제시한다. 중심단어 : 신체활동, 에너지대사, 호르몬, 식욕 REFERENCES 1. Kim MJ, Park HC, Jung AR, Yoon SJ. The effects of intermittent brisk or continuant brisk walking on fat metabolism. Korean J Phys Educ 2009;48(4): Thompson WR, Gordon NF, Pescatello LS; American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. 8th ed. Philadelphia, PA:Lippincott Williams & Wilkins;2010. p King NA, Blundell JE. High-fat foods overcome the energy expenditure induced by high-intensity cycling or running. Eur J Clin Nutr 1995;49(2): King NA, Burley VJ, Blundell JE. Exercise-induced suppression of appetite: effects on food intake and implications for energy balance. Eur J Clin Nutr 1994;48(10): Dickson-Parnell BE, Zeichner A. Effects of a short-term exercise program on caloric consumption. Health Psychol 1985; 4(5): Leal-Cerro A, Garcia-Luna PP, Astorga R, Parejo J, Peino R, Dieguez C, et al. Serum leptin levels in male marathon athletes before and after the marathon run. J Clin Endocrinol Metab 1998;83(7): Landt M, Lawson GM, Helgeson JM, Davila-Roman VG, Ladenson JH, Jaffe AS, et al. Prolonged exercise decreases serum leptin concentrations. Metabolism 1997;46(10): Weltman A, Pritzlaff CJ, Wideman L, Considine RV, Fryburg DA, Gutgesell ME, et al. Intensity of acute exercise dose not affect serum leptin concentrations in young men. Med Sci Sports Exerc 2000;32(9): King NA, Tremblay A, Blundell JE. Effects of exercise on appetite control: implications for energy balance. Med Sci Sports Exerc 1997;29(8): Jeong IG. New Sports Nutrition. Seoul:Dkbooks;2000. p Fisher JS, Van Pelt RE, Zinder O, Landt M, Kohrt WM. Acute exercise effect on postabsorptive serum leptin. J Appl Physiol 2001;91(2): Andersson B, Larsson B. Influence of local temperature changes in the preoptic area and rostral hypothalamus on the regulation of food and water intake. Acta Physiol Scand 1961;52: Mayer J. Bulletin of the New England Medical Center, Volume XIV, April-June 1952: The glucostatic theory of regulation of food intake and the problem of obesity (a review). Nutr Rev 1991;49(2): Harris RB, Martin RJ. Recovery of body weight from below "set point" in mature female rats. J Nutr 1984;114(6): Louis-Sylvestre J, Le Magnen J. Fall in blood glucose level precedes meal onset in free-feeding rats. Neurosci Biobehav Rev 1980;4 Suppl 1: Yoon SW, Kim KJ, Kim CG, Kim HD, Kim H. Essentials of Strength Training and Conditioning. Seoul:Daehanmedia;2002. p Ormsbee MJ, Choi MD, Medlin JK, Geyer GH, Trantham LH, Dubis GS, et al. Regulation of fat metabolism during resistance exercise in sedentary lean and obese men. J Appl Physiol 2009; 106(5): Ormsbee MJ, Thyfault JP, Johnson EA, Kraus RM, Choi MD, Hickner RC. Fat metabolism and acute resistance exercise in trained men. J Appl Physiol 2007;102(5):

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Lumbar spine

Lumbar spine CT 32 111 DOI : 10.3831/KPI.2010.13.2.111 Lumbar Spine CT 32 Received : 10. 05. 23 Revised : 10. 06. 04 Accepted : 10. 06. 11 Key Words: Disc herniation, CT scan, Clinical analysis The Clinical