KISEP Information Korean J Otolaryngol 2005;48:284-8 NF-κB의 활성화와 면역학적 기능 채 성 원 Function and Activation of NF-κB in Immune System Sung Won Chae, MD, PhD Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea - - - - - - - - - - - 284
채성원 Table 1. NF-B and IKK proteins Protein Other names NF-B proteins p50 p105 NF-B1, p110, KBF1, EBO-1 p52 p100 NF-B2, p50b, p49, p55, Lyt10, H2TF1 RelA p65 I-Rel IB kinase IKK proteins IKK IKK1, CHUK IKK IKK2 IKK IKK3, NEMO NF-B essential modulator Viruses TLRs Cytokines Proinflmmatory Antigen cytokines receptors LTR, BAFF, CD40L IKK IKK IKK IB p50 p65 p50 p65 mrna IKK IKK p52 NIK p100 mrna proteins proteins GGG Ankyrin repeats p52 Target genes GGG p50 V- Rel RelA p65 Innate immunity Inflammation Cell survival Fig. 2. Classical and alternative NF-κB pathway. AThe classical NF-κB pathway is activated by a variety of inflammatory signals. BThe alternative NF-κB pathway is strictly dependent on IKKα homodimers and is activated by NIK. IKKIκB kinase, NIKNFκB-inducing kinase, LTlymphotoxin, BAFFB-cell activating factor belong to the TNFG family, CD40LCD40 ligand. L Z C-Rel Fig. 1. NF-κB proteins contain a well conserved Rel-homology domain. Some proteins, such as c-rel, and RelA, contain transactivation domains in addition to the. - - - - - 285
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