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CNIC94-01 1 行 94 年 1 1 94 年 12 31 95 年 02 27 1

老行不利酪力 DPPH TEAC 利 MPA580 料行類參年量利領歷理來易度易理來更力了歷數更年更爲便更 2

老留識流列流識來來陸 Hu, G. (Chrysanthemum ramat) (Crocus sativus L) 精 (2-hydroxy-4-methoxybenzophenone-5-sulfonic acid) 力不力論令例蘆金金縷例料蘆 A. barbadensis MilleAloe vera extract 金 Calendula officinal Calendula extract 刺狀 L. Matricaria chamomilla. L. Chamomile fluid extract Zingiber officinale Ginger root extract 金縷 Hamamelis virginiana L. Hamaelis extract Rosmarinus Rosemary extract or oil 3

officinalis L. 茶 Melaleuca alternifolia Ch. Tea tree oil 狀 Triticum sp. Wheat germ oil 1. 力 DPPH (1,1-diphenyl-2-picryl hydrazyl) 375ul sample 20mg/l DPPH 750ul 30 517nm ABTS free radical 1.5ml 離 ABTS(1000uM) 0.25ml H 2 O 2 (500uM)0.25ml Peroxidase (44units/ml)0.25ml 1 0.25ml 10 734nm Liposome system 1cc Liposome(10mg/1cc NaH 2 PO 4 -Na 2 HPO 4 ) 1cc FeCl 3 (400uM) 1cc 1cc Ascorbic Acid(400uM) 36 0.1cc TBHQ(10mg/1cc ) 2cc TCA-TBA-HCL 100 15 4

2000rpm 離 10 535nm 2. 酪量精 70 units mushroom tyrosinase 0.5 ml L-tyrosine (0.1 mg/ml) 37 60 利度量 475 nm 100 酪酪 3. 2 ml 0.01 % (0.123 mg/ 5 ml 12.5 g methylene chloride, 37.5 g cyclohexane, 50 g isopropanol) 250~400 nm 行數 5

(2 mg/cm 2 ) (Transpore TM tape) In vitro SPF ( UV1000S) 量 280~400 nm 率率 SPF 4. 老不度 extracts 3 I III 行力老力例丹 30 (Glycyrrhiza glabra) (twig of Morus alba) (root-bark of Morus alba) 丹 (Paeonia suffruticosa ANDREWS) (Chaenomeles speciosa) 酪力 30 (Glycyrrhiza glabra L.) (Citrus reticulate Blanco) (Scutellaria baricalensis GEORGI) 金 (Lonicera japonica Thunb) 連 (Coptis chinensis Franch) 丹參 (Salvia 6

miltiorrhiza Bge) (Phellodendron chinense schneid) 力連老力論流 ; 來更流力列療六參 1. Bernard, P. and Berthon, J. Y. 2000. Resveratrol: an original mechanism on tyrosinase inhibition. International journal of Cosmetic Science. 22, 219-226. 2. Boots the chemist Ltd. The guide to practical measurement of UVA/UVB ratios. The Boots Chemist, PLC, Nottingham, England. 3. Cabanes, J. et al. 1994. Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase. J. Pharm. Pharmacol. 46, 982-985. 4. Cosmetics & toiletries 1996. Natural and Botanical products formulary. Vol 111, 81-94. 5. Easton, A. Women have deadly desire for paler skin in the 7

Philippines. The Lancet 352, 555. 6. Fitzpartrick, T. B. 1995. Pathophysiology of hypermelanoses. Clin. Drug. Invest. 10 (suppl. 2) 7. Goihman-Yahr, M. 1996. Skin aging and photoaging: an outlook. Clinics in Dermatology. 14,153-160. 8. Lee, K. T. et al., 1997. Biological screening of 100 plant extracts for cosmetic use (I): inhibitory activities of tyrosinase and DOPA auto-oxidation. International Journal of Cosmetic Science. 19, 291-298. 9. Lin, C.-G., Kao, Y.-T., Liu, W.-T., Huang, H.-H., Chen, K.-C. and Lin, H.-C. 1996. Cytotoxic effects of Bacillus anthracis lethal toxin on macrophage-like cell line. Current Microbiology 33, 224-227. 10. Luckewicz, W. 1990. Determination of ascorbly dipalmitate in cosmetic whitening powders by differential scanning calorimetry. J. Soc. Cosmet. Chem. 41. 359-367. 11. Maeda K. et al. 1991. In vitro effectiveness of several whitening cosmetic components in human melanocytes. J. Soc. Cosm. Chem. 42, 361-368. 12. Masuda, M. et al. 1996. Skin lighteners. Cosmet. Toil. 111, 65-75. 13. Melo, P. S., Duran, N., and Haun, M. Cytotoxicity of prodigisin and benznidazole on V79 cells. 2000. Toxicology letters 116, 237-242. 14. Merot, F., Seniuta, R., Benita, G. and Masson, Ph. 1992. Method for quantifying cutaneous pigmentation in animals and preliminary study in humans. International Journal of Cosmetic Science. 14, 173-182. 15. Motoyoshi, K., Ota, Y., Takuma, Y. and Takenouchi, M. 1998. Wrinkles from UVA exposure. 113, 51-56. 16. Phillips, B. J. 1996. Development of cell culture techniques for assessment of the toxicity of plant products. Toxicology in vitro 10, 69-76. 17. Schallreuter, K. U. et al. 1994. Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin. Science 263. 1444-1446. 18. Shin, N. H. et al. 1998. Oxyresveratrol as the potent inhibitor on dopa oxidase activity of mushroom tyrosinase. Biochememical And Biophysical Research Communications. 243, 801-803. 19. Shirota, S. et al. 1994. Tyrosinase inhibitors from crude drugs. Biol. Pharm. Bull. 17, 266-269. 8

20. Smith, J. 1996. State of the industry: the Asia-Pacific cosmetics and toiletries sector, 1995. DCI. 24-34. 21. Stern, M. Klausner, M., Alvarado, R., Renskers, K., and Dickens, M. 1998. Evaluation of the EpiOcular tissue model as an alternative to the Draize eye irritation test. Toxicology in vitro 12, 455-461. 9